Original publications


Reyes JF, Rey NL, Bousset L, Melki R, Brundin P, Angot E (2013). Alpha-synuclein transfers from neurons to oligodendrocytes.  Glia. 2013 Dec 31. doi: 10.1002/glia.22611. [Epub ahead of print]

George S, Petit GH, Gouras GK, Brundin P, Olsson R (2013) Nonsteroidal selective androgen receptor modulators and selective estrogen receptor b agonists moderate cognitive deficits and amyloid-b levels in a mouse model of Alzheimer’s disease. ACS Chem Neurosci. 2013 Sep 10. [Epub ahead of print]. Abstract. PDF george-2013-acs-chem-neurosci.

Rey NL, Petit GH, Bousset L, Melki R, Brundin P (2013) Transfer of human a-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol. 2013 Aug 8. [Epub ahead of print]. Abstract. PDF rey-2013-acta neuropathol.

Hansen C, Björklund T, Petit GH, Lundblad M, Murmu RP, Brundin P, Li JY (2013) A novel a-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of a-synuclein-GFP. Neurobiol Dis. 2013 Apr 30;56C:145-155. doi:10.1016/j.nbd.2013.04.017. Abstract. PDF hansen-2013-neurobiol-dis

Petit GH, Berkovich E, Hickery M, Kallunki P, Fog K, Fitzer-Attas C and Brundin P (2013) Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson´s disease. PLoS One 8(4):e60691Abstract. PDF petit-2013-plos-one

Rahman A, Ekman M, Shakirova Y, Andersson KE, Mörgelin M, Erjefält JS, Brundin P, Li JY, Swärd K. (2013) Late onset vascular dysfunction in the R6/1 model of Huntington’s disease. Eur J Pharmacol. 698(1-3):345-53. Abstract. PDF rahman-2013-eur-j-pharmacol


Angot E, Steiner J, Lema Tomé CM, Ekström P, Mattsson B, Björklund A and Brundin P (2012) Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo. PLoS One, 7(6):e39465. Abstract. PDF angot-2012-plos-one

Jeon I, Lee N, Li JY, Park IH, Park KS, Moon J, Shim SH, Choi C, Chang DJ, Kwon J, Oh SH, Shin DA, Kim HS, Do JT, Lee DR, Kim M, Kang KS, Daley GQ, Brundin P, Song J (2012) Neuronal properties, in vivo effects and pathology of a Huntington’s disease patient-derived induced pluripotent stem cells. Stem Cells, 30(9):2054-62. doi:10.1002/stem.1135. Abstract. PDF jeon-2012-Stem-Cells

Paul G, Özen I, Christophersen N, Reinbothe T, Bengzon J, Visse E, Jansson K, Dannaeus K, Henriques-Oliveira C, Roybon L, Anisimov S, Renström E, Svensson M, Haegerstrand A and Brundin P (2012) The adult human brain harbors multipotent perivascular mesenchymal stem cells. PLoS One, 7(4):e35577. Abstract. PDF paul-2012-plos-one


van der Burg JM, Winqvist A, Aziz NA, Maat-Schieman ML, Roos RA, Bates GP, Brundin P, Björkqvist M and Wierup N (2011) Gastrointestinal dysfunction contributes to weight loss in Huntington’s disease mice. Neurobiol Dis 44: 1-8 Abstract. PDF van der burg-2011-neurobiol

Kurowska Z, Englund E, Widner H, Lindvall O, Li JY and Brundin P (2011) Signs of Degeneration in 12–22-Year Old Grafts of Mesencephalic Dopamine Neurons in Patients with Parkinson’s Disease. J Park Dis 1: 83-92. Abstract. PDF kurowska-2011-j-park-dis

Grey M, Linse S, Nilsson H, Brundin P and Sparr E (2011) Membrane Interaction of alpha-synuclein in different aggregation states. J Park Dis 1: 359-371. Abstract. PDF grey-2011-j-park-dis

Carlsson T, Schindler FR, Höllerhage M, Depboylu C, Arias-Carrión O, Schnurr-busch S, Rösler TW, Wozny W, Schwall GP, Groebe K, Oertel WH, Brundin P, Schrattenholz A and Höglinger GU (2011) Systemic administration of neuregulin-1?1 protects dopaminergic neurons in a mouse model of Parkinson’s disease. J Neurochem 117: 1066-74. Abstract. PDF carlsson-2011-neurochem

Duarte AI, Petit GH, Ranganathan S, Li JY, Oliveira CR, Brundin P, Björkqvist M and Rego AC (2011) IGF-1 protects against diabetic features in an in vivo model of Huntington’s disease. Exp Neurol 231: 314-9. Abstract. PDF duarte-2011-exp-neurol

Fedele V, Roybon L, Nordström U, Li JY and Brundin P (2011) Neurogenesis in R6/2 mouse model of Huntington’s disease is impaired at the level of NeuroD1. Neuroscience 173: 76-81. Abstract. PDF fedele-2011-neuroscience

Gaughwin, PM, Ciesla M, Lahiri N, Tabrizi S, Brundin P* and Björkqvist M* (2011) Hsa-miR-34b is a plasma-stable microRNA that is elevated in premanifest Huntington’s disease. Hum Mol Genet 20: 2225-37. *Joint senior authors. Abstract. PDF gaughwin-2011-hum-mol-gen

Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, Cano J, Brundin P, Englund E, Venero JL and Joseph B (2011) Caspase signalling controls microglia activation and neurotoxicity. Nature, 472: 319-24. Abstract PDF burguillos-2011-nature

Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li JY and Brundin P (2011) alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. Journal of Clinical Investigations. 121: 715-725 Abstract PDF hansen-2011-j-clin-invest

Gaughwin P, Ciesla M, Yang H, Lim B and Brundin P (2011) Stage-Specific Modulation of Cortical Neuronal Development by Mmu-miR-134. Cerebral Cortex, 21:1857-59. Abstract. PDF gaughwin-2011-cereb-cortex

Anisimov SV, Christophersen NS, Correia AS, Hall VJ, Sandelin I, Li JY and Brundin P (2011) Identification of molecules derived from human fibroblast feeder cells that support the proliferation of human embryonic stem cells. Cellular and Molecular Biology Letters 16: 79-88. Abstract. PDF anisimov-2011-cell-mol-biol-lett

van der Borght K, Köhnke R, Göransson N, Deierborg T, Brundin P, Erlanson-Albertsson C and Lindqvist A (2010) Reduced neurogenesis in the rat hippocampus following high fructose consumption. Regulatory Peptides 167: 26-30.  Abstract PDF van_der_broght-2010-regl.pept


Morizane A, Darsalia V, Guloglu MO, Hjalt T, Carta M, Li JY and Brundin P (2010) A simple method for large-scale generation of dopamine neurons from human embryonic stem cells. Journal of Neuroscience Research 88:3467-3478. Abstract. PDF morizane-2010-j-neurosci-res

Deierborg T, Roybon L, Inacio AR, Pesic J and Brundin P (2010) Brain injury activates microglia that induce neural stem cell proliferation ex vivo and promotes differentiation of neurosphere-derived cells into neurons and oligodendrocytes. Neuroscience 171:1386-1396. Abstract. PDF deierborg-2010-neuroscience

Fedele V, Roybon L, Nordström U, Li JY and Brundin P (2010) Neurogenesis in R6/2 mouse model of Huntington’s disease is impaired at the level of NeuroD1. Neuroscience 173:76-81. Abstract. PDF fedele-2010-neuroscience

Carreira BP, Morte MI, Inácio A, Costa G, Rosmaninho-Salgado J, Agasse F, Carmo A, Couceiro P, Brundin P, Ambrósio AF, Carvalho CM and Araújo IM (2010) Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor. Stem Cells 28: 1219-1230. Abstract. PDF carriera-2010-stem-cell

Li JY, Englund E, Widner H, Rehncrona S, Björklund A, Lindvall O and Brundin P (2010) Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson’s disease. Movement Disorders 25: 1091-1096. Abstract. PDF li-2010-mov-disord

Lee HS, Bae EJ, Yi SH, Shim JW, Jo AY, Kang JS, Yoon EH, Rhee YH, Park CH, Koh HC, Kim HJ, Choi HS, Han JW, Lee YS, Kim J, Li JY, Brundin P and Lee SH (2010) Foxa2 and Nurr1 Synergistically Yield A9 Nigral Dopamine Neurons Exhibiting Improved Differentiation, Function and Cell Survival. Stem Cells 28:501-512. Abstact. PDF lee-2010-stem-cells


Smith R, Bacos K, Fedele V, Soulet D, Walz HA, Obermüller S, Lindqvist A, Björkqvist M, Klein P, Onnerfjord P, Brundin P, Mulder H and Li JY (2009) Mutant huntingtin interacts with beta-tubulin and disrupts vesicular transport and insulin secretion. Human Molecular Genetics 18:3942-3954. Abstract. PDF smith-2009-hum-mol-genet

Roybon L, Mastracci TL, Ribeiro D, Sussel L, Brundin P and Li JY (2009) GABAergic Differentiation Induced by Mash1 Is Compromised by the bHLH Proteins Neurogenin2, NeuroD1, and NeuroD2. Cerebral Cortex 20:1234-1244. Abstract. PDF roybon-2009-cerebal-cortex

Khoshnan A, Ko J, Tescu S, Brundin P and Patterson PH (2009) KKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin. PLoS ONE 4:e5768. Abstract. PDF khoshnan-2009-plos-one

Maynard CJ, Böttcher C, Ortega Z, Smith R, Florea BI, Brundin P, Overkleeft HS, Li JY, Lucas JJ, Dantuma NP (2009) Accumulation of ubiquitylated proteins in a polyglutamine disease model is not due to impairment of the ubiquitin/proteosome system. Proceedings of the National Academy of Sciences USA 106:13986-13991. Abstract. PDF maynard-2009-pnas

Deierborg T, Staflin K, Pesic J, Roybon L, Brundin P and Lundberg C (2009) Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries. Experimental Neurology 219:363-367. Abstract. PDF deierborg-2009-exp-neurol

Lane EL, Vercammen L, Brundin P* and Cenci MA* (2009) Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats. Experimental Neurology 219:355-358. *Shared senior authors. Abstract. PDF lane-2009-exp-neurol

Lane EL, Brundin P* and Cenci MA* (2009) Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson’s disease. Neurobiology of Disease 35:42-51. *Shared senior authors. Abstract. PDF lane-2009-neurobiol-dis

Roybon L, Deierborg T, Brundin P and Li JY (2009) Involvement of Ngn2, Tbr and NeuroD1 proteins during postnatal olfactory bulb neurogenesis. European Journal of Neuroscience 29:232-243. Abstract. PDF roybon-2009-eur-j-neurosci

Roybon L, Hjalt T, Stott S, Guillemot F, Li JY and Brundin P (2009) Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis. PLoS ONE 4:e4779. Abstract. PDF roybon-2009-plos-one


Björkqvist M, Wild EJ, Thiele J, Silvestroni A, Andre R, Lahiri N, Raibon E, Lee RV, Benn CL, Soulet D, Magnusson A, Woodman B, Landles C, Pouladi MA, Hayden MR, Khalili-Shirazi A, Lowdell MW, Brundin P, Bates GP, Leavitt BR, Möller T and Tabrizi SJ (2008) A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington’s disease.  Journal of Experimental Medicine 205:1869-1877. Abstract. PDF bjorkqvist-2008-jem

Lane EL, Soulet D, Vercammen L, Cenci MA* and Brundin P* (2008) Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson’s disease. Neurobiology of  Disease 32:220-228. *Shared senior authors. Abstract. PDF lane-2008-neurobiol-dis

Aziz NA, van der Burg JM, Landwehrmeyer GB, Brundin P, Stijnen T, EHDI Study Group and Roos RA (2008) Weight loss in Huntington disease increases with higher CAG repeat number. Neurology 71:1506-1513. Abstract.

Fountaine TM, Venda LL, Warrick N, Christian HC, Brundin P, Channon KM and Wade-Martins R (2008) The effect of alpha-synuclein knockdown om MPP+ toxicity in models of human neurons. European Journal of Neuroscience 28:2459-2473. Abstract. PDF fountain-2008-Eur-J-Neurosci

Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Björklund A, Widner H, Revesz T, Lindvall O and Brundin P (2008) Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation. Nature Medicine 14:501-503. Abstract. PDF li-2008-nat-med

Wood NI, Goodman AOG, van der Burg JMM, Gazeau V, Brundin P, Björkqvist M, Petersen Å, Tabrizi SJ, Barke RA and Morton AJ (2008) Increased thirst and drinking in Huntington’s disease and the R6/2 mouse. Brain Reseach Bullentin 76:70-79. Abstract. PDF wood-2008-brain-research-bulletin

Roybon L, Hjalt T, Christophersen NS, Li JY and Brundin P (2008) Effects on differentiation of Embryonic Ventral Midbrain Progenitors by Lmx1a, Msx1, Ngn2, and Pitx3. Journal of Neuroscience 28:3644-3656. Abstract. PDF roybon-2008-journal-of-neuroscience

Araujo IM, Gil JM, Carreira BP, Mohapel P, Petersen A, Pinheiro PS, Soulet D, Bahr BA, Brundin P and Carvalho CM (2008) Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus. Journal of Neurochemistry 105:666-676. Abstract. PDF araujo-2008-j-neurochem

Bacos K, Björkqvist M, Petersén A, Luts L, Maat-Schieman ML, Roos RA, Sundler F, Brundin P, Mulder H, Wierup N (2008) Islet beta-cell area and hormone expression are unaltered in Huntington’s disease. Histochemistry and Cell Biology 129:623-629. Abstract. PDF bacos-2008-histochem-cell-biol

van der Burg JM, Bacos K, Wood NI, Lindqvist A, Wierup N, Woodman B, Wamsteeker JI, Smith R, Deierborg T, Kuhar MJ, Bates GP, Mulder H, Erlanson-Albertsson C, Morton AJ, Brundin P, Petersén A, Björkqvist M (2008) Increased metabolism in the R6/2 mouse model of Huntington’s disease. Neurobiology of Disease 29:41-51. Abstract. PDF vanderburg-2008-neurobiology-of-disease


Björkqvist M, Leavitt BR, Nielsen JE, Landwehrmeyer B, Ecker D, Mulder H, Brundin P, Petersén A (2007) Cocaine- and amphetamine-regulated transcript is increased in Huntington disease. Movement Disorder 22:1952-1954. Abstract. PDF bjorkqvist-2007-mov-disord

Smith R, Klein P, Koc-Schmitz Y, Waldvogel HJ, Faull RL, Brundin P, Plomann M and Li JY (2007) Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington’s disease. Journal of Neurochemistry 103:115-123. Abstract. PDF smith-2007-j-neurochem

Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén Å, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M. Tabrizi SJ (2007) Proteomic profiling of plasma in Huntington’s disease reveals neuroinflammatory activation and biomarker candidates. Journal of Proteome Research 6:2833-2840. Abstract. PDF dalrymple-2007-j-proteome-res

Paul G, Christophersen NS, Raymon H, Kiaer C, Smith R and Brundin P (2007) Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line – studies in vitro and after intracerebral grafting in vivo. Molecular and Cellular Neuroscience 34: 390-399. Abstract. PDF paul-2007-molecular-and-cellular-neuroscience

Christophersen NS, Grønborg M, Petersen TN, Fjord-Larsen L, Jørgensen JR, Juliusson B, Blom N, Rosenblad C and Brundin P (2007) Midbrain expression of Delta-like 1 homologue is regulated by GDNF and is associated with dopaminergic differentiation. Experimental Neurology 204: 791-801. Abstract. PDF christophersen-2007-experimental-neurology

Anisimov SV, Christophersen NS, Correia AS, Li J-Y and Brundin P (2007) “NeuroStem Chip”: a novel highly specialized tool to study neural differentiation pathways in human stem cells. BMC Genomics 8: 46. Abstract, PDF anisimov-2007-bmc-genomics

van der Borght K and Brundin P (2007) Reduced expression of PSA-NCAM in the hippocampus and piriform cortex of the R6/1 and R6/2 mouse models of Huntington’s disease. Experimental Neurology 204: 473-478. Abstract, PDF vanderborght-2007-experimental-neurology

Fahrenkrug J, Popovic N, Georg B, Brundin P and Hannibal J (2007) Decreased VIP and VPAC2 receptor expression in the biological clock of the R6/2 Huntington disease mouse. Journal of Molecular Neuroscienceb 31:139-148. Abstract, PDF fahrenkrug-2007-journal-of-molecular-neuroscience-mn


Lane EL, Winkler C, Brundin P and Cenci MA (2006) The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat. Neurobiology of disease 22:334-345. Abstract, PDF lane-2006-neurobiology-of-disease

Westin JE, Lindgren HS, Gardi J, Randel Nyengaard J, Brundin P, Mohapel P and Cenci MA (2006) Endothelial proliferation and increased blood–brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia. Journal of Neuroscience 26:9448-9461. Abstract. PDF westin-2006-journal-of-neuroscience

Smith R, Chung H, Rundquist S, Maat-Schieman MLC, Colgan L, Englund E, Liu YJ, Roos RAC, Faull RLM, Brundin P and Li JY (2006) Cholinergic neuronal defect without cell loss in Huntington’s disease. Human Molecular Genetics 15:3119-3131. Abstract. PDF smith-2006-human-molecular-genetics

Mohapel P, Mundt-Petersen K, Brundin P and Frielingsdorf H (2006) Working memory training decreases hippocampal neurogenesis. Neuroscience 142:609-613. Abstract. PDF mohapel-2006-neuroscience

Lindqvist A, Mohapel P, Bouter B, Frielingsdorf H, Pizzo D, Brundin P and Erlanson-Albertsson C (2006) High-fat diet impairs hippocampal neurogenesis in male rats. European Journal of Neurology 13:1-4. Abstract. PDF lindqvist-2006-eur-j-neurol

Christophersen NS, Meijer X, Jorgensen JR, Englund U, Gronborg M, Seiger A, Bjorklund A, Brundin P and Wahlberg LU (2006) Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain. Brain Research Bulletin 70: 457-466 . Abstract. PDF christophersen-2006-brain-research-bulletin

Nygren J, Wieloch T, Pesic J, Brundin P and Deierborg T (2006) Enriched environment attenuates cell genesis in SVZ after focal ischemia in mice and decreases migration of newborn cells to the striatum. Stroke 37:2824-2829. Abstract. PDF nygren-2006-stroke

Brederlau A, Correia AS, Anisimov S, Elmi M, Roybon L, Paul G, Morizane A, Bergquist F, Riebe I, Nannmark U, Carta M, Hanse E, Takahashi J, Sasai Y, Funa K, Brundin P, Eriksson PS and Li J-Y (2006) Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson’s disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells 24:1433-1440. Abstract. PDF brederlau-2006-stem-cells

Roybon L, Ma Z, Asztely F, Fosum A, Jacobsen S-E, Brundin P and Li J-Y (2006) Failure of transdifferentiation of adult hematopoietic stem cells into neurons. Stem Cells 24:1594-1604. Abstract. PDF roybon-2006-stem-cells

Bjorkqvist M, Petersén A, Bacos K, Isaacs J, Norlén P, Gil J, Popovic N, Sundler F, Bates GP, Tabrizi SJ, Brundin P and Mulder H (2006) Progressive Alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington´s disease. Human molecular genetics 15:1713-1721. Abstract, PDF bjorkqvist-2006-human-molecular-genetics

Bjorkqvist M, Petersen A, Nielsen J, Ecker D, Mulder H, Hayden MR, Landwehrmeyer B, Brundin P and Leavitt BR (2006) Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington Disease. Clinical Genetics 70:78-79. Abstract. PDF bjorkqvist-2006-clin-genet


Papalexi E, Persson A, Bjorkqvist M, Petersen A, Woodman B, Bates GP, Sundler F, Mulder H, Brundin P and Popovic N (2005) Reduction of GnRH and infertility in the R6/2 mouse model of Huntington’s disease. European Journal of Neuroscience 22:1541-1546. Abstract, PDF papalexi-2005-eur-j-neurosci

Roybon L, Brundin P and Li JY (2005) Stromal cell-derived inducing activity does not promote dopaminergic differentiation, but enhances differentiation and proliferation of neural stem cell-derived astrocytes. Experimental Neurology 196:373-380. Abstract, PDF roybon-2005-experimental-neurology

Karlsson J, Petersén A, Gido G, Wieloch T and Brundin P (2005) Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient. Cell Transplantation 5:14301-14309. Abstract.

Lotharius J, Falsig J, van Beek J, Payne S, Dringen R, Brundin P and Leist M (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. Journal of Neuroscience 6:6329-6342. Abstract, PDF lotharius-2005-journal-of-neuroscience

Gil JM, Mohapel P, Araujo IM, Popovic N, Li JY, Brundin P and Petersén A (2005) Reduced hippocampal neurogenesis in R6/2 transgenic Huntington’s disease mice. Neurobiology of Disease 20:744-751. Abstract, PDF gil-2005-neurobiology-of-disease

Ahn YH, Bensadoun JC, Aebischer P, Zurn A, Bjorklund A, Lindvall O, Wahlberg L, Brundin P and Kaminski Schierle GS (2005) Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial-cell line derived neurotrophic factor. Brain Research Bulletin 30:135-142. Abstract, PDF ahn-2005-brain-research-bulletin

Smith R, Petersén A, Bates G, Brundin P and Li JY (2005) Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington’s Disease, a possible culprit in synaptic dysfunction. Neurobiology of Disease 20:673-684. Abstract, PDF smith-2005-neurobiology-of-disease

Iancu R, Mohapel P, Brundin P and Paul G (2005) Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson’s disease in mice. Behavioural Brain Research 162:1-10. Abstract, PDF iancu-2005-behavioural-brain-research

Mohapel P, Frielingsdorf H, Haggblad J, Zachrisson O and Brundin P (2005) Platelet-Derived Growth Factor (PDGF-BB) and Brain-Derived Neurotrophic Factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience 132:767-776. Abstract, PDF mohapel-2005-neuroscience

Petersén A, Gil J, Maat-Schieman M, Bjorkqvist M, Tanila H, Araújo IM, Smith R, Popovic N, Wierup N, Norlén , Li JY, Roos RAC, Sundler F, Mulder H, and Brundin P (2005) Orexin loss in Huntington’s disease. Human Molecular Genetics 14:39-47. Abstract, PDF petersen-2005-human-molecular-genetics

Popovic N, Maingay M, Kirik D and Brundin P (2005) Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes. Experimental Neurology 193:65-74. Abstract, PDF popovic-2005-experimental-neurology

Araujo IM, Xapelli S, Gil JM, Mohapel P, Petersen A, Pinheiro PS, Malva JO, Bahr BA, Brundin P and Carvalho CM (2005) Proteolysis of NR2B by calpain in the hippocampus of epileptic rats. Neuroreport 16:393-396. Abstract.

Puschban Z, Stefanova N, Petersen A, Winkler C, Brundin P, Poewe W and Wenning GK (2005) Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy. Brain Research Bullentin 68:54-58. Abstract, PDF puschban-2005-brain-research-bulletin

Bjorkqvist M, Fex M, Renstrom E, Wierup N, Petersen A, Gil J, Bacos K, Popovic N, Li JY, Sundler F, Brundin P and Mulder H (2005) The R6/2 transgenic mouse model of Huntington’s disease develops diabetes due to deficient beta-cell mass and exocytosis. Human Molecular Genetics 14:565-574.  Abstract, PDF bjorkqvist-2005-human-molecular-genetics1


Frielingsdorf H, Schwarz K, Brundin P and Mohapel P (2004) No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proceedings of the National Academy of Sciences of the United States of America 101:10177-10182. Abstract, PDF frielingsdorf-2004-proceedings-of-the-national-academy-of-sciences

Gil J MAC, Leist M, Popovic N, Brundin P and Petersén A (2004) Asialoerythropoetin is not effective in the R6/2 line of Huntington’s disease mice. BMC Neuroscience 5:17
Abstract, PDF gil-2004-bmc-neurosci


Ahn YH, Emgard M and Brundin P (2003) Ultrastructural characterization of dissociated embryonic ventral mesencephalic tissue treated with neuroprotectants. Cell Transplantation 3:235-241. Abstract, PDF ahn-2003-cell-transplantation

Emgard M, Hallin U, Karlsson J, Bahr BA, Brundin P and Blomgren K (2003) Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue: a role for protease activation. Journal of Neurochemistry 5:1223-1232. Abstract, PDF

Maciel EN, Kaminski Schierle GS, Hansson O, Brundin P and Castilho RF (2003) Cyclosporin A and Bcl-2 do not inhibit quinolinic acid-induced striatal excitotoxicity in rodents. Experimental Neurology 2:430-437. Abstract, PDF maciel-2003-experimental-neurology

Hansson O, Nylandsted J, Castilho RF, Leist M, Jaattela M and Brundin P (2003) Overexpression of heat shock protein 70 in R6/2 Huntington’s disease mice has only modest effects on disease progression. Brain Research 970:47-57. Abstract, PDF hansson-2003-brain-research

Larsson LC, Corbascio M, Pearson TC, Larsen CP, Ekberg H and Widner H (2003) Induction of operational tolerance to discordant dopaminergic porcine xenografts. Transplantation 15:1448-1454. Abstract.


Love RM, Branton RL, Karlsson J, Brundin P and Clarke DJ (2002) Effects of antioxidant pretreatment on the survival of embryonic dopaminergic neurons in vitro and following grafting in an animal model of Parkinson’s disease. Cell Transplantation 11:653-662. Abstract, PDF love-2002-cell-transplantation

Emgard M, Blomgren K and Brundin P (2002) Characterisation of cell damage and death in embryonic mesencephalic tissue: a study on ultrastructure, vital stains and protease activity. Neuroscience 115:1177-1187. Abstract, PDF emglrd-2002-neuroscience

Petersén A, Puschban Z, Lotharius J, Nicniocaill B, Wiekop P, O’Connor WT and Brundin P (2002) Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington’s disease mice. Neurobiology of Disease 11:134-146. Abstract, PDF petersen-2002-neurobiology-of-disease

Karlsson J, Emgard M and Brundin P (2002) Comparison between survival of lazaroid-treated embryonic nigral neurons in cell suspensions, cultures and transplants. Brain Research 2002 15:268-280. Abstract, PDF karlsson-2002-brain-research

Lotharius J, Barg S, Wiekop P, Lundberg C, Raymond HK and Brundin P (2002). Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. Journal of Biological Chemistry 277:38884-38894. Abstract, PDF lotharius-2002-journal-of-biological-chemistry

Hagell P, Piccini P, Bjorklund A, Brundin P, Rehncrona S, Widner H, Crabb L, Pavese N, Oertel WH, Quinn N, Brooks DJ and Lindvall O (2002). Dyskinesias following neural transplantation in Parkinson’s disease. Nature Neuroscience 5:627-628. Abstract, PDF hagell-2002-nat-neurosci

Petersen A, Chase K, Puschban Z, DiFiglia M, Brundin P and Aronin N (2002) Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington’s disease. Experimental Neurology 175:297-300. Abstract, PDF petersen-2002-experimental-neurology

Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR and Raymond LA (2002) Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington’s disease. Neuron 33:849-860. Abstract, PDF zeron-2002-neuron

Larsson LC, Corbascio M, Widner H, Pearson TC, Larsen CP and Ekberg H (2002) Simultaneous inhibition of B7 and LFA-1 signaling prevents rejection of discordant neural xenografts in mice lacking CD40L. Xenotransplantation 9:68-76. Abstract, PDF larsson-2002-xenotransplantation


Petersén A, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S and Brundin P (2001) Mice transgenic for exon 1 of the Huntington gene display reduced sensititvity to neurotoxicity induced by intrastriatal injections of dopamine and 6-hydroxydopamine. European Journal of Neuroscience 14:1425-1435. Abstract, PDF petersen-2001-european-journal-of-neuroscience

Hansson O, Guatteo E, Mercuri NB, Bernardi G, Li XJ, Castilho RF and Brundin P (2001) Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene. European Journal of Neuroscience 14:1492-1504. Abstract, PDF hansson-2001-eur-j-neurosci

Petersén A, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P and Sulzer D (2001) Expanded CAG repeats in exon 1 of the Huntington’s disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration. Human Molecular Genetics 10:1243-1254. Abstract, PDF petersen-2001-human-molecular-genetics

Petersen A, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P and Sulzer D (2001) Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death. Brain Research Bulletin 56:331-335. Abstract, PDF petersen-2001-brain-research-bullentin

Hansson O, Castilho RF, Korhonen L, Lindholm D, Bates GP and Brundin P (2001) Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington’s disease is dependent on age and CAG repeat length. Journal of Neurochemistry 78:694-703. Abstract, PDF hansson-2001-j-neurochem

Larsson LC, Frielingsdorf H, Mirza B, J:dtr Hansson S, Anderson P, Czech KA, Strandberg M and Widner H (2001) Porcine neural xenografts in rats and mice: donor tissue development and characteristics of rejection. Experimental Neurology 172:100-114. Abstract, PDF larsson-2001-experimental-neurology

Nicniocaill B, Haraldsson B, Hansson O, O’Connor WT and Brundin P (2001) Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice. European Journal of Neuroscience 13:206-210. Abstract, PDF nicniocaill-2001-eur-j-neurosci

Wennberg L, Czech KA, Larsson L, Mirza B, Bennett W, Song Z and Widner H (2001) Effects of immunosuppressive treatment on host responses and survival of porcine neural xenografts in rats. Transplantation 71:1797-1806. Abstract.

Larsson LC, Anderson P, Widner H and Korsgren O (2001) Enhanced survival of porcine neural xenografts in mice lacking the CD1.1; but no effect of NK1.1 depletion. Cell Transplantation 10:295-304. Abstract


Petersén A, Hansson O, Emgard M and Brundin P (2000) Grafting of nigral tissue hibernated with tirilazad mesylate and glial cell line-derived neurotrophic factor. Cell Transplantation 9:577-584.
Abstract, PDF petersen-2000-cell-transplant

Hansson O, Castilho RF, Kaminski Schierle GS, Karlsson J, Nicotera P, Leist M and Brundin P (2000) Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons. Experimental Neurology 164:102-111. Abstract, PDF hansson-2000-experimental-neurology

Mundt-Petersen U, Petersén A, Emgard M, Dunnett SB and Brundin P (2000) Caspase inhibition increases embryonic striatal graft survival. Experimental Neurology 164:112-120. Abstract, PDF mundt-petersen-2000-experimental-neurology

Castilho RF, Hansson O and Brundin P (2000) FK506 and Cyclosporin A enhance the survival of cultured and grafted rat embryonic dopamine neurons. Experimental Neurology 164:94-100. Abstract, PDF castilho-2000-experimental-neurology

Brundin P, Pogarell O, Hagell P, Piccini P, Widner H, Schrag A, Kupsch A, Crabb L, Odin P, Gustavii B, Bjorklund A, Brooks DJ, David Marsden C, Oertel WH, Quinn NP, Rehncrona S and Lindvall O (2000) Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson’s disease. Brain 123:1380-1390. Abstract, PDF brundin-2000-brain

Karlsson J, Emgard M, Brundin P and Burkitt MJ (2000) Transresveratrol protects embryonic mesencephalic cells from tertbutyl hydroperoxide: electron paramagnetic spin trapping evidence for a radical scavenging mechanism. Journal of Neurochemistry 75:141-150. Abstract, PDF karlsson-2000-j-neurochem

Karlsson J, Emgard M, Gido G, Wieloch T and Brundin P (2000) Increased survival of embryonic nigral neurons when grafted to hypothermic rats. Neuroreport 11:1665-1668. Abstract

Larsson L, Czech KA, Brundin P and Widner H (2000) Intrastriatal porcine ventral mesencephalic tissue xenografts in rats: immune responses and functional effects. Cell Transplantation 9:261-272. Abstract

Mundt-Petersen U, Karlsson J, Schierle GS and Brundin P (2000) Pretreatment with MK-801 or the lazaroid U-83836E does not enhance striatal graft survival. Cell Transplantation 9:73-78. Abstract

Petersén A, Castilho RF, Hansson O, Wieloch T and Brundin P (2000) Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons. Brain Research 857:20-29. Abstract, PDF petersen-2000-brain-research


Petersén A and Brundin P (1999) Effects of ciliary neurotrophic factor on excitotoxicity and calcium-ionophore A23187-induced cell death in cultured embryonic striatal neurons. Experimental Neurology 160:402-412. Abstract, PDF petersen-1999-experimental-neurology

Piccini P, Brooks DJ, Bjorklund A, Gunn RN, Grasby PM, Rimoldi O, Brundin P, Hagell P, Rehncrona S, Widner H and Lindvall O (1999) Dopamine release from nigral transplants visualized in vivo in a Parkinson’s patient. Nature Neuroscience 2:1137-1140.
Abstract, PDF piccini-1999-nat-neurosci

Petersén A, Emgard M and Brundin P (1999) Impact of a preceding excitotoxic lesion and treatment with ciliary neurotrophic factor on striatal graft survival. Brain Research Bulletin 50:275-281. Abstract, PDF petersen-1999-brain-research-bulletin

Kaminski Schierle GS, Hansson O, Ferrando-May E, Nicotera P, Brundin P and Leist M (1999) Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation. Neuro-report 10:3347-3351. Abstract

Emgard M, Karlsson J, Hansson O and Brundin P (1999) Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts. Experimental Neurology 160:279-288. Abstract, PDF emglrd-1999-experimental-neurology

Schierle GS, Leist M, Martinou JC, Widner H, Nicotera P and Brundin P (1999) Differential effects of Bcl-2 overexpression on fiber outgrowth and survival of embryonic dopaminergic neurons in intracerebral transplants. European Journal of Neuroscience 11:3073-3080. Abstract, PDF schierle-1999-eur-j-neurosci

Larsson LC, Czech KA, Widner H and Korsgren O (1999) Discordant neural tissue xenografts survive longer in immuno-globulin deficient mice. Transplantation 27:1153-1160. Abstract

Sumitran S, Anderson P, Widner H and Holgersson J (1999) Porcine embryonic brain cell cytotoxicity mediated by human natural killer cells. Cell Transplantation 8:601-610. Abstract

Kaminski Schierle GS, Hansson O and Brundin P (1999) Flunarizine improves the survival of grafted dopaminergic neurons. Neuroscience 94:17-20. Abstract, PDF kaminski-schierle-1999-neuroscience

Larsson LC, Duan WM and Widner H (1999) Discordant xenografts: different outcome after mouse and rat neural tissue transplantation to guinea pigs. Brain Research Bulletin 49:367-376. Abstract, PDF larsson-1999-brain-research-bulletin

Hansson O, Petersén A, Leist M, Nicotera P, Castilho RF and Brundin P (1999) Transgenic mice expressing a Huntington’s disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity. Proceedings of the National Academy of Sciences USA 96:8727-8732. Abstract, PDF hansson-1999-proceedings-of-the-national-academy-of-sciences

Hagell P, Schrag A, Piccini P, Jahanshahi M, Brown R, Rehncrona S, Widner H, Brundin P, Rothwell JC, Odin P, Wenning GK, Morrish P, Gustavii B, Bjorklund A, Brooks DJ, Marsden CD, Quinn NP and Lindvall O (1999) Sequential bilateral transplantation in Parkinson’s disease: effects of the second graft. Brain 122:1121-1132. Abstract, PDF hagell-1999-brain

Sumitran S, Liu J, Czech KA, Christensson B, Widner H and Holgersson J (1999) Human natural antibodies cytotoxic to pig embryonic brain cells recognize novel non-Gal alpha 1,3 Gal-based xenoantigens. Experimental Neurology 159:347-361. Abstract, PDF sumitran-1999-experimental-neurology

Schierle GS and Brundin P (1999) Excitotoxicity plays a role in the death of tyrosine hydroxylase-immunopositive nigral neurons cultured in serum-free medium. Experimental Neurology 157:338-348. Abstract, PDF schierle-1999-experimental-neurology

Schierle GS, Hansson O, Leist M, Nicotera P, Widner H and Brundin P (1999) Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nature Medicine 5:97-100. Abstract, PDF schierle-1999-nat-med

Karlsson J, Love RM, Clarke DJ and Brundin P (1999) Effects of anaesthetics and lazaroid U-83836E on survival of transplanted rat dopaminergic neurones. Brain Research 821:546-550. Abstract, PDF karlsson-1999-brain-research1

Grasbon T, Grasbon-Frodl EM, Juliusson B, Epstein C, Brundin P, Kampik A and Ehinger B (1999) CuZn superoxide dismutase transgenic retinal transplants. Graefes Archives of Clinical and Experimental Ophthalmology 237:336-341. Abstract, PDF grasbon-1999-graefes-archive-for-clinical-and-experimental-ophthalmology


Karlsson J, Emgard M, Rosenblad C and Brundin P (1998) Treatment with the spin-trap agent a-phenyl-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons. Brain Research 805:155-168. Abstract, PDF karlsson-1998-brain-research

Duan WM, Widner H, Cameron RM and Brundin P (1998) Quinolinic acid-induced inflammation in the striatum does not impair the survival of neural allografts in the rat. European Journal of Neuroscience 10:2595-2606. Abstract

Schierle GS, Karlsson J and Brundin P (1998) MK-801 does not enhance dopaminergic cell survival in embryonic nigral grafts. Neuroreport 9:1313-1316. Abstract


Duan WM, Cameron RM, Brundin P and Widner H (1997). Rat intrastriatal neural allografts challenged with skin allografts at different time-points. Experimental Neurology 148:334-347. Abstract, PDF duan-1997-experimental-neurology

Othberg A, Keep M, Brundin P and Lindvall O (1997) Tirilazad mesylate improves survival of rat and human embryonic dopamine neurons in vitro. Experimental Neurology 147:498-502. Abstract, PDF othberg-1997-experimental-neurology

Emgard-Mattson M, Karlsson J, Nakao N and Brundin P (1997) Addition of lateral ganglionic eminence to rat mesencephalic grafts affects fiber outgrowth but does not enhance function. Cell Transplantation 6:277-286. Abstract, PDF emgard-mattson-1997-cell-transplant

Grasbon-Frodl EM, Nakao N, Lindvall O and Brundin P (1997) Developmental features of human striatal tissue transplanted in a rat model of Huntington’s disease. Neurobiology of Disease 3:299-311. Abstract, PDF grasbon-frodl-1997-neurobiology-of-disease

Wenning GK, Odin P, Morrish P, Rehncrona S, Widner H, Brundin P, Rothwell JC, Brown R, Gustavii B, Hagell P, Jahanshahi, Sawle G, Bjorklund A, Brooks DJ, Marsden CD, Quinn NP and Lindvall O (1997). Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson’s disease. Annals of Neurology 42:95-107. Abstract

Barkats M, Nakao N, Grasbon-Frodl EM, Biland-Bleuel A, Revah F, Mallet J and Brundin P (1997) Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase. Neuroscience 78:703-713. Abstract, PDF barkats-1997-neuroscience

Duan WM, Brundin P and Widner H (1997) Addition of allogeneic spleen cells causes rejection of intrastriatal embryonic mesencephalic allografts in the rat. Neuroscience 77:599-609. Abstract, PDF duan-1997-neuroscience

Grasbon-Frodl EM and Brundin P (1997). Mesencephalic neuron death induced by congeners of nitrogen monoxide is prevented by the lazaroid U-83836E. Experimental Brain Research 113:138-143. Abstract

Nakao N and Brundin P (1997) Effects of a-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid. Neuroscience 76:749-761. Abstract, PDF nakao-1997-neuroscience


Grasbon-Frodl EM, Andersson A and Brundin P (1996) Lazaroid treatment prevents death of cultured rat embryonic mesencephalic neurons following glutathione depletion. Journal of Neurochemistry 67:1653-1660. Abstract

Nakao N, Grasbon-Frodl EM, Widner H and Brundin P (1996) DARPP-32 rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled pawreaching in an animal model of Huntington’s disease. Neuroscience 74:959-970. Abstract, PDF nakao-1996-neuroscience-1

Nakao N, Grasbon-Frodl EM, Widner H and Brundin P (1996) Antioxidant treatment protects striatal neurons against excitotoxic insults. Neuroscience 73:185-200. Abstract, PDF nakao-1996-neuroscience

Grasbon-Frodl EM, Nakao N, Lindvall O and Brundin P (1996) Phenotypic development of the human embryonic striatal primordium: a study of cultured and grafted neurons from the lateral and medial ganglionic eminences. Neuroscience 73:171-183. Abstract, PDF grasbon-frodl-1996-neuroscience

Grasbon-Frodl EM, Nakao N and Brundin P (1996) The lazaroid U-83836E improves the survival of rat embryonic mesencephalic tissue stored at 4 degrees C and subsequently used for cultures or intracerebral transplantation. Brain Research Bulletin 39:341-348. Abstract, PDF grasbon-frodl-1996-brain-research-bulletin

Duan WM, Brundin P, Grasbon-Frodl EM and Widner H (1996) Methylprednisolone prevents rejection of intrastriatal grafts of embryonic neural tissue in rats. Brain Research 712:199-212. Abstract, PDF duan-1996-brain-research

Nakao N, Odin P, Lindvall O and Brundin P (1996) Differential trophic effects of basic fibroblast growth factor, insulin-like growth factor-1, and neurotrophin-3 on striatal neurons in culture. Experimental Neurology 138:144-157. Abstract, PDF nakao-1996-experimental-neurology


Frodl EM, Sauer H, Lindvall O and Brundin P (1995) Effects of hibernation or cryopreservation on the survival and integration of striatal grafts placed in the ibotenate-lesioned rat caudate putamen. Cell Transplantation 4:571-577. Abstract

Nakao N, Brundin P, Lindvall O and Odin P (1995) Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32 containing neurons in vitro. Developmental Brain Research 90:92-101. Abstract

Duan WM, Widner H and Brundin P (1995) Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats. Experimental Brain Research 104:227-242. Abstract

Nakao N, Frodl EM, Widner H, Carlson E, Eggerding FA, Epstein CJ and Brundin P (1995) Overexpressing Cu/Zn-superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson’s disease. Nature Medicine 1:226-231. Abstract

Duan WM, Widner H, Frodl EM and Brundin P (1995) Immune reactions following systemic immunization prior or subsequent to intrastriatal implantation of allogeneic mesencephalic tissue in rats. Neuroscience 64:629-641. Abstract, PDF duan-1995-neuroscience